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Multiple Sclerosis: Update Bulletin #3 [August 2018]

Product Code:
Publication Date:
August 2018

This edition presents key opinion leader (KOL) views on recent developments in the multiple sclerosis (MS) market. Topics covered include: TG Therapeutics announcing updated results from a Phase II multicentre trial of ublituximab (TG 1101) in relapsing forms of multiple sclerosis (RMS); Roche presenting new Phase III data analyses for Ocrevus (ocrelizumab), and announcing the initiation of two additional Phase IIIb studies; as well as Alkermes announcing receipt of a US$50 million payment from Biogen relating to diroximel fumarate (formerly ALKS 8700) following Biogen's review of preliminary gastrointestinal tolerability data.

Business Questions:

• What are KOLs’ reactions to the updated Phase II results for ublituximab in patients with relapsing forms of MS?
• According to KOLs, is ublituximab’s shorter infusion time an advantage?
• Could ublituximab compete with Ocrevus and ofatumumab?
• How do KOLs view the new data analyses showing Ocrevus may provide meaningful disability benefits such as delay in the need for a wheelchair for people with PPMS?
• What do the experts think of the two new Ocrevus Phase IIIb trials, ORATORIO-HAND and CONSONANCE?
• According to experts, how clinically attractive is diroximel fumarate and what potential challenges need to be considered in order to position this therapy?


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