Melanoma: KOL Insight [2017]

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Publication Date:
November 2017
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Are novel therapies set to revolutionise malignant melanoma?

Despite advances in the treatment of malignant melanoma (MM), demand still persists for improved modalities and outcomes. Newer targeted and immunotherapy combinations are emerging from the late-stage pipeline, but in a competitive landscape which assets will stand out? Want to find out more? Learn how KOLs see the malignant melanoma market evolving in Melanoma: KOL Insight (2017).

Twelve US and European KOLs provide candid insights on 9 marketed and 7 pipeline therapies targeting various aspects of the MM treatment algorithm.

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Top takeaways

  • Immune-oncology agents dominate the melanoma scene. Can Merck & Co.’s Keytruda maintain its position as the anti-PD-1 agent of choice? What advice do experts have for BMS’ Opdivo?
  • Toxicity for BMS’ Yervoy remains a concern. Is the therapy on its way out or can lower dose (3mg/kg) Yervoy be as effective as the high dose (10mg/kg); find out what KOLs think?
  • KOLs anticipate Opdivo will win approval in the adjuvant setting based on CheckMate-238 data. How will Keytruda’s KEYNOTE-054 study impact BMS’ franchise and which checkpoint inhibitor is likely to win?
  • Single agent BRAF/MEK inhibitors are rarely prescribed but which combination (Roche’s Zelboraf/Cotellic or GSK’s Mekinist/Tafinlar) do KOLs favour? Array’s new encorafenib/binimetinib combination is on the way; can it compete?
  • Is there any future for Amgen’s Imlygic? Viewed as a niche product by experts, can combination therapy with immune-oncology agents salvage Imlygic?
  • Does Incyte’s IDO inhibitor, epacadostat have any potential? How do experts rate this novel mechanism of action for melanoma?
  • What do experts say about Novartis’ PDR 001 and Roche’s atezolizumab? How do they rate the chances of these novel checkpoint inhibitors in light of ever increasing competition?
  • Anti-PD-1/BRAF/MEK combinations are on the horizon. Which triplet regimens hold the most promise and what concerns do experts have with these multi-drug combinations?
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“The more we learn about mechanisms of both de novo and acquired resistance and what the underpinnings for melanoma subsets that are particularly hard to treat, I think we're going to have a much bigger toolbox to put things together and really move the [treatment] plateaus up a bit more.”
EU Key Opinion Leader

“I'm excited about the IDO inhibitor paradigm and other combinations that can be designed, in an intelligent way, to get at particular cases that are non-responsive to single agent drugs.”
EU Key Opinion Leader

Sample of therapies covered

Marketed Therapies

  • Cotellic (Exelixis/Roche)
  • IMLYGIC (Amgen)
  • Keytruda (Merck & Co.)
  • Mekinist (Novartis)
  • M-Vax (AVAX Technologies)
  • Opdivo (Bristol-Myers Squibb/Ono Pharmaceuticals)
  • Tafinlar (Novartis)
  • Yervoy (Bristol-Myers Squibb)
  • Zelboraf (Roche/Genentech/Chugai)

Pipeline Therapies

  • Atezolizumab (Genentech/Roche)
  • Binimetinib (Array BioPharma; Novartis)
  • Darleukin (Philogen)
  • Encorafenib (Array BioPharma/Novartis)
  • Epacadostat (Incyte/Merck & Co.)
  • PDR 001 (Novartis)
  • Seviprotimut-L (Polynoma)

KOLs interviewed

KOLs from North America

  • Anna C Pavlick, DOProfessor, Hematology and Medical Oncology and Medical Director Perlmutter Cancer Center Clinical Trials Office NYU Langone Medical Center, New York City, NY
  • Kim A Margolin, MDMedical Oncologist, Clinical Professor, City of Hope, Department of Medical Oncology & Therapeutics Research, University of Washington, Seattle, WA
  • Philip A. Friedlander MD, PhDAssistant Professor, Department of Dermatology, Mount Sinai School of Medicine, New York City, NY
  • Rene-Gonzalez_Catarelo MDOncology Specialist, Memorial Hospital and University of Colorado Hospital, Aurora, Denver, CO
  • Roger S. Lo, MD, PhDAssistant Professor, Medicine and Molecular & Medical Pharmacology, Department of Medicine at UCLA, Los Angeles, CA
  • Sanjiv S Agarwala, MD, Professor, Temple University School of Medicine, Chief of Medical Oncology and Hematology, St. Luke’s University Hospital & Health Network, Bethlehem, Philadelphia, PA

KOLs from Europe

  • Ana Arance MD, PhDProfessor, Department of Medical Oncology, Hospital Clínic Barcelona, Villarroel 170, 08036 Barcelona, Spain
  • Anonymous German KOLProf. Dr., Professor of Dermatology and Director at a teaching hospital in Germany
  • Christian Blank, MD, PhDProfessor Dr, Group Leader Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands
  • Jean-Jacques Grob, MDHead of the Dermatology and Skin cancer Department, Timone APHM Hospital and Aix-Marseille University, Marseille, France
  • Paul D Nathan, MBBS, PhD, FRCPConsultant Medical Oncologist, Mount Vernon Cancer Centre, East and North Herts NHS Trust, Northwood, Middlesex, UK
  • Caroline Robert, MD, PhDProfessor & Head of the Dermatology Unit at the Gustave Roussy Cancer Centre, Villejuif-Paris, France

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